Retrosynthetic Analysis

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• Resynthesis of active molecules
• Predict the best pathways to compound synthesis
• Utilize available reagents and building blocks

Many CROs are experienced with retrosynthetic analysis and can help discover the best pathways to resynthesis of active compounds for drug discovery. They utilize complex computer models to mine route databases rapidly including Elsevier, MOS, and Beilstein to discover validated synthesis approaches

Retrosynthetic analysis often is outsourced to CRO structural chemistry specialists to save time and direct a structure based drug design process. The goal is to generate simple validated synthesis pathways by mining the work of published chemists. Retrosynthesis analysis can be used to direct new libraries from a known active drug or compound, leading to discovery of drugs with increased potency.

Once predictive pathways are identified via retrosynthetic analysis they can be tested rapidly for high-throughput production of APIs or libraries based on an active compound.

Proven structural chemistry design and analysis is a useful step in drug discovery and the launch of new pharmaceuticals. CROs can advise you on the best methods necessary to rapidly advance your APIs through the drug formulation process.