Determination of leukocyte chemotaxis in response to well characterized chemotactic agents or test compounds.

Determination of testing compounds cytotoxic activity

Evaluate IC50 for 1 compound on 5 diverse tumor cell lines under normoxia and hypoxia

Evaluate compound effect on TNF-α-stimulated release of 2 cytokines from cultured human bronchial epithelial cells

Determination of adhesion and migration of leukocytes to endothelial cells.

Evaluate compound effect on LPS-stimulated release of 2 cytokines from cultured human alveolar macrophages

Evaluate compound effect on LPS-stimulated release of 2 cytokines (e.g. TNF-α and IL-6) from cultured human monocytes.

Evaluate compound effect on anti-CD3-stimulated release of 2 cytokines (e.g. IL-2 and IFN-γ) from human lymphocytes.

Antibody-dependent cell-mediated cytotoxicity assay for therapeutic antibody/Fc fusion proteins

Evaluate compound effect on LPS-stimulated release of 2 cytokines (e.g. TNF-α and IL-6) from cultured human blood.

Evaluate compound effect on TNF-α-induced release of 2 cytokines (e.g. IL-6 and IL-8) from primary human hepatocytes

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Profiling of small molecules for cytotoxicity using organotypic liver slice cultures

Quantitative determination of anticoagulant activity of testing compounds

Quantitative 4- or 9-plex determination of cytokine release from fresh PBMC in response to pro-inflammatory stimulation